Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing 4,6-Dimethyl-pyrimidin-2-ylthio Group

作     者：许良忠 建方方 时建刚 李琳 

作者机构：New Materials & Functional Coordination Chemistry Laboratory Qingdao University of Science and Technology Qingdao Shandong 266042 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2004年第22卷第7期

页      面：1308-1312页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Project supported by the Educational Administration Key Project of Shandong Province (No. J01C05) and the Natural Science Foundation of Shan-dong Province (No. Y2002B06) 

主　　题：dimethyl-2-mercaptopyrimidine 1,2,4-triazole substituted-acetylbenzene crystal structure biological activity 

摘      要：Four compounds were prepared by reacting 4,6-dimethyl-2-mercaptopyrimidine with -bromo--(1,2,4- triazol-1-yl)-substituted acetylbenzene. Their structures were identified by means of elemental analysis, IR, and 1H NMR spectra. The single crystal structure of 2-[1-(1,2,4-triazol-1-yl)-1-p-methoxyphenylcarbonylmethylthio]-4,6- dimethyl-pyrimidine was also determined. It crystallizes in monoclinic system, space group P21/c, a=0.8016(2) nm, b=1.2462(3) nm, c=1.7824(4) nm, =99.89(3), Z=4, V=1.7540(7) nm3, Dc=1.346 g/cm3, =0.205 mm-1, F(000)=744, final R1=0.0452. There is obviously potentially weak C—H…N intermolecular interaction between the molecules in the crystal lattice, which stabilizes the crystal structure. The result of the biological test showed that the four compounds all have some fungicidal and plant growth regulating activities.