O-glycosylation in liver cancer:Clinical associations and potential mechanisms

作     者：Kung-Hao Liang Chau-Ting Yeh Kung-Hao Liang;Chau-Ting Yeh

作者机构：Liver Research CenterChang Gung Memorial HospitalTaoyuanTaipeiChina Medical Research DepartmentTaipei Veterans General HospitalTaipeiChina Molecular Medicine Research CenterChang Gung UniversityTaoyuanTaipeiChina 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2017年第1卷第4期

页      面：193-196页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This project was supported by Chang Gung Medical Foundation(CMRPG1B0571 CIRPG3B0032 CMRPG3F1601) 

主　　题：O-glycosylation Post-translational modification Glycobiology Biomarkers Hepatocellular carcinoma(HCC) Glycosyltransferase 

摘      要：Liver cancer can be an aggressive disease,and is highly prevalent in Asia and ***,its currently approved therapeutic strategies are far from *** progress in genomic,proteomic and glycomic profiling technologies have enabled the identification of biomarkers that significantly correlate with clinical *** biomarkers are related to O-glycosylation of glycoproteins,which belong to an important but less-explored field of liver cancer ***,we review these clinical studies and discuss potential underlying mechanisms.