Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery

作     者：Liang Qiu Linfei Zhao Chengfen Xing Yong Zhan 

作者机构：Institute of BiophysicsHebei University of Technology 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2018年第29卷第2期

页      面：301-304页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No. 21574037) the"100 Talents" Program of Hebei Province, China(No. E2014100004) the Natural Science Foundation of Hebei Province(Nos. B2015202330, B2017202051) the Program for Top 100 Innovative Talents in Colleges and Universities of Hebei Province(No.SLRC2017028) the Tianjin Natural Science Foundation(No. 15JCYBJC17500) 

主　　题：Redox responsive Drug delivery system Hybrid nanoparticles NSET effect 

摘      要：A drug carrier system of the hybrid nanoparticles based on the redox-responsive P[（2-（（2-（（camptothecin）-oxy）ethyl）disulfanyl）ethylmethacrylate）-co-（2-（D-galactose）methylmethacryl-ate）]（P（MACPTS-co-MAGP）） and AgNPs is developed to deliver the anti-cancer drug camptothecin（CPT） and monitor the drug release by the recovery of the fluorescence of CPT. CPT is linked to the polymer sidechains via a redox-responsive disulfide bond, attaching on the surface of AgNPs and leading to the quenching of CPT fluorescence（ ＂off＂ state） due to the nanoparticle surface energy transfer（NSET） effect.Upon the exposure to glutathione（GSH）, the disulfide bond is cleaved to release CPT, resulting in the recovery of the fluorescence of CPT（＂on＂ state）. The system offers a platform to track the CPT delivery and releasing in real time