Layered double hydroxide using hydrothermal treatment： morphology evolution, intercalation and release kinetics of diclofenac sodium

作     者：Mathew JOY SrividhyaJ. IYENGAR Jui CHAKRABORTY Swapankumar GHOSH 

作者机构：Project Management Division CSIR-Central Glass & Ceramic Research Institute Kolkata-700032 India Bioceramics & Coating Division CSIR-Central Glass & Ceramic Research Institute Kolkata-700032 India 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2017年第11卷第4期

页      面：395-409页

核心收录：

学科分类：08[工学] 

基　　金：Council of Scientific and Industrial Research  India  CSIR  (ESC-0103) 

主　　题：layered double hydroxide crystal morphology hydrothermal treatment drug loading 

摘      要：The present work demonstrates the possibilities of hydrothermal trans- formation of Zn-AI layered double hydroxide （LDH） nanostructure by varying the synthetic conditions. The manipulation in washing step before hydrothermal treatment allows control over crystal morphologies, size and stability of their aqueous solutions. We examined the crystal growth process in the presence and the absence of extra ions during hydrothermal treatment and its dependence on the drug （diclofenac sodium （Dic- Na）） loading and release processes. Hexagonal plate-like crystals show sustained release with -90% of the drug from the matrix in a week, suggesting the applicability of LDH nanohybrids in sustained drug delivery systems. The fits to the release kinetics data indicated the drug release as a diffusion-controlled release process. LDH with rod-like morphology shows excellent colloidal stability in aqueous suspension, as studied by photon correlation spectroscopy.