mTORC1 signaling in hepatic lipid metabolism
mTORC1 signaling in hepatic lipid metabolism作者机构:MOE Key Laboratory of Bioinformatics Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China
出 版 物:《Protein & Cell》 (蛋白质与细胞(英文版))
年 卷 期:2018年第9卷第2期
页 面:145-151页
核心收录:
学科分类:12[管理学] 120203[管理学-旅游管理] 081702[工学-化学工艺] 1202[管理学-工商管理] 08[工学] 0817[工学-化学工程与技术]
基 金:国家自然科学基金 National Key Research Program of China
主 题:mTOR mTORC1 lipogenesis lipophagy
摘 要:The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. DysregulaUon of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.