PP2A Inhibits Cervical Cancer Cell Migration by Dephosphorylation of p-JNK,p-p38 and the p-ERK/MAPK Signaling Pathway

作     者：Hong-yun ZHENG Fu-jin SHEN Yong-qing TONG Yan LI 郑红云;申复进;童永清;李艳

作者机构：Department of Clinical LaboratoryRenmin Hospital of Wuhan University Clinical Molecular Diagnostic CenterRenmin Hospital of Wuhan University Department of GynecologyRenmin Hospital of Wuhan University 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2018年第38卷第1期

页      面：115-123页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81100959) Natural Science Foundation of Hubei Province(Nos.2015CFB185,2015CFB723) National Clinical Key Specialty Construction Projects of Ministry of Health of China(No.2010-305) 

主　　题：protein phosphatase 2A HeLa cells migration mitogen-activated protein kinases 

摘      要：Protein phosphatase 2 A（PP2 A） was reported to play an important role in cancer development;however,the relationship between PP2 A and cervical cancer development has yet to be fully *** present study aimed to explore the role of PP2 A in the development of cervical *** levels of PP2 A were detected by ELISA in 23 patients with cervical cancer and 30 patients with benign cervical ***,the PP2 A activities and the m RNA and protein levels of PP2 A were measured in cervical cancer（n=8） and chronic cervicitis（n=10） *** results showed that the serum levels of PP2 A were significantly reduced in patients with cervical *** studies showed that not only the activities of PP2 A but also the m RNA and protein levels of PP2 A were significantly decreased in cervical cancer *** healing and Transwell assays demonstrated that pharmacological and genetic upregulation of PP2 A could inhibit the migration of He La cells,but the downregulation of PP2 A promoted cellular *** activation of PP2 A also inhibited the remodeling of actin and the activity of mitogen-activated protein kinases（MAPKs） including p-JNK,p-p38 and ***,the activation of PP2 A was found to downregulate MMP-9 levels,which further inhibited the migration and invasion of He La *** conclusion,our data suggest that the activity and expression of PP2 A are significantly reduced in cervical cancer tissues,and the activation of PP2 A may inhibit the migration of cervical cancer cells by inhibiting the phosphorylation of p-JNK,p-p38 and the p-ERK/MAPK signaling pathway as well as by downregulating MMP-9,implying that PP2 A plays an important role in cervical cancer development.