Down-regulation of Helios Expression in Tregs from Patients with Hypertension

作     者：Zhu-yue CHEN Feng CHEN Yan-ge WANG Ding-hang WANG Li-li JIANG Long-xian Cheng 陈朱越;陈凤;王燕鸽;王定航;蒋丽丽;程龙献

作者机构：Laboratory of Cardiovascular Immunology Institute of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Adult Internal Medicine Hubei Maternal and Child Health Hospital Wuhan 430070 China 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2018年第38卷第1期

页      面：58-63页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81370324) 

主　　题：hypertension cardiovascular disease regulatory T cells Helios Foxp3 

摘      要：Regulatory T cells（Tregs） play a pivotal role in the pathological development of ***,a transcription factor from the Ikaros family,was recently reported to be a bona fide marker for natural Tregs or activated Tregs with suppression function,however,little has been known about its role in *** study was aimed to find whether Helios＋ Tregs really play a vital role in hypertension.A total of 60 hypertension patients,and 46 normotension subjects were enrolled in this *** of different Tregs subsets in peripheral blood were measured by flow *** cytokine level was determined by *** m RNA expression of Foxp3 and Helios in purified CD4＋ T cells was detected by *** of CD4＋Foxp3＋Helios＋ Tregs was decreased significantly in patients with hypertension（62.52%±1.18% vs.71.89%±1.03%,P〈0.01）,and it was correlated with plasma level of IL-10 positively（r=0.505,P〈0.05） and plasma level of IFN-gamma negatively（r=–0.551,P〈0.05）.The m RNA expression of Foxp3（7.23±1.00 vs.10.58±0.54,P〈0.05） and Helios（8.47±0.95 vs.15.52±2.0,P〈0.05） was decreased in CD4＋ T cells from patients with ***＋ Tregs were decreased in patients with hypertension and may play a protective role in hypertension progression.