Post-irradiation pericardial malignant mesothelioma with deletion of p16: a case report

作     者：Yalda B.Naeini Ramir Arcega Sharon Hirschowitz Nagesh Rao Haodong Xu 

作者机构：Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLA 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2018年第15卷第1期

页      面：97-102页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Pericardial malignant mesothelioma p16 deletion post-irradiation Hodgkin's lymphoma 

摘      要：Malignant mesotheliomas are rather uncommon neoplasms associated primarily with asbestos exposure; however, they may also arise as second primary malignancies after radiation therapy, with a latency period of 15–25 years. Numerous studies have reported an association between pleural malignant mesothelioma and chest radiation performed for other malignancies; on the other hand, post-irradiation mesotheliomas of the pericardium have been reported in only a few published cases to date, and no homozygous deletion of 9 p21 has been described in such cases. We report the case of a 48-year-old man with a history of Hodgkin s lymphoma and no prior asbestos exposure who developed pericardial malignant epithelioid mesothelioma. We further discuss the cytologic, histologic, immunophenotypic, and fluorescence in situ hybridization findings in this case. To our knowledge, this is the first well-documented case of post-radiation pericardial malignant mesothelioma showing homozygous deletion of 9 p21. Homozygous deletion of 9 p21, the locus harboring the p16 gene, is present in post-irradiation pericardial malignant mesothelioma.