Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism

作     者：Ke An Fengxia Du Hao Meng Guochao Li Minjie Zhang Zongzhi Liu Zitong Zhao Zilong Zhang Di Yu Dong Wang Caiyun Yang Wencui Ma Lin Yuan Meiting Zhou Lili Duan Li Jin Hui Li Yan Zhang Jianzhong Su Jie Qiao Yingli Sun 

作者机构：Key Laboratory of Genomic and Precision Medicine China Gastrointestinal Cancer Research Center Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Heze Third People's Hospital Heze 274000 China Department of Nuclear Medicine Fengxian Central Hospital Shanghai 116044 China Weihai Municipal Hospital Weihai 264200 China State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai 200433 China College of Bioinformatics Science and Technology Harbin Medical University Harbin 150081 China College of Biomedical Engineering Wenzhou Medical University Wenzhou 325035 China Reproductive Medical Center Department of Obstetrics and Gynecology Peking University Third Hospital Key Laboratory of Assisted Beijing 100191 China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2018年第45卷第3期

页      面：169-172页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.31540033 and91131002) the Precision Medicine Research Program of the Chinese Academy of Sciences(KJZD-EW-L14) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12020343) the National Basic Research Program of China(2013CB911001 and 2012CB518302) the National Excellent Youth Science Foundation of China(No.31222030) 

主　　题：Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP Seq links epigenetic inheritance to metabolism 

摘      要：Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails（Zhang and Reinberg,2001）.It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development（Fischle et al.,2005）.