Relationship between metabolic enzyme activities and bioaccumulation kinetics of PAHs in zebrafish(Danio rerio)

作     者：Haotian Wang Yayuan Li Xinghui Xia Xinyue Xiong 

作者机构：State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2018年第30卷第3期

页      面：43-52页

核心收录：

学科分类：082803[工学-农业生物环境与能源工程] 07[理学] 08[工学] 0828[工学-农业工程] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

基　　金：supported by the National Science Foundation for Distinguished Young Scholars (No.51325902) the National Natural Science Foundation of China (No.91547207) the National Natural Science Foundation for Innovative Research Group (No.51421065) 

主　　题：Hydrophobic organic compounds(HOCs)lBioaccumulationlMetabolismlCytochrome P450lTotal superoxide dismutase (T SOD)lZebrafish 

摘      要：Many studies have investigated bioaccumulation and metabolism of polycyclic aromatic hydrocarbons（PAHs）in aquatic ***,lack of studies investigated both processes simultaneously,and the interaction between these two processes is less understood so *** study investigated the bioaccumulation kinetics of PAHs and metabolic enzyme activities,including total cytochrome P450（CYPs）and total superoxide dismutase（T-SOD）,in *** zebrafish were exposed to the mixture of phenanthrene and anthracene under constant concentration maintained by passive dosing systems for 16 *** results showed that PAH concentrations in zebrafish experienced a peak value after exposure for 1.5 days,and then decreased *** bioaccumulation equilibrium was achieved after exposure for 12 *** of the uptake rate constants（ku）and the elimination rate constants（ke）decreased after the peak *** variation of PAH concentrations and metabolic enzyme activities in zebrafish had an interactive *** activities of CYPs and T-SOD increased initially with the increase of PAH concentrations,but decreased to the lowest state when PAH concentrations reached the peak *** the bioaccumulation equilibrium of PAHs was achieved,CYPs and T-SOD activities also reached the steady *** general,CYPs and T-SOD activities were activated after exposure to *** decrease of PAH concentrations in zebrafish after the peak value may be attributed to the great drop of kuand the variation of CYPs *** study suggests that an interactive relationship exists between bioaccumulation kinetics of PAHs and metabolic enzyme activities in aquatic organisms.