Cardioprotective effects of combination of notoginseng total saponins and safflower total flavonoids against myocardial infarction in rats

作     者：Yuqing Meng Lichao Wang Yan Li Jinyang Song Zhiyong Du Chun Li Yong Jiang Pengfei Tu Xiaoyu Guo 孟雨晴;王丽超;李岩;宋金洋;杜智勇;李春;姜勇;屠鹏飞;郭晓宇

作者机构：State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100191 China State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2018年第27卷第2期

页      面：116-122页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：National Natural Sciences Foundation of China(Grant No.81573684) 

主　　题：Myocardial infarctions Inflammation Apoptosis Notoginseng Radix et Rhizoma Carthami Flos 

摘      要：In this study, the cardioprotective mechanism of the combination of notoginseng total saponins and safflower total flavonoids（CNS） was investigated due to its excellently efficacy against myocardial infarction（MI） in rats. After the left anterior descending coronary artery（LADCA） ligation, rats were orally administered with CNS for 7 consecutive days. CNS prevented MI-induced pathophysiological changes and significantly decreased plasma levels of myocardial enzymes, including creatine kinase MB isoenzyme（CK-MB）, lactate dehydrogenase（LDH） and aspartate aminotransferase（AST）. Further investigation revealed that CNS attenuated the production of inflammatory factors in plasma, including tumor necrosis factor-alpha（TNF-α）, interleukin-6（IL-6） and interleukin-1β（IL-1β）. Moreover, CNS treatment decreased the expression of caspase-3 at the mR NA level in infarct tissue. Our findings demonstrated that the anti-inflammatory and anti-apoptotic properties of CNS might confer its cardioprotection against MI in rats.