Development and optimization of nanoemulsion gel for topical delivery of imiquimod

作     者：Gurvinder Kaur Tanurajvir Kaur Deepak N.Kapoor Gurvinder Kaur;Tanurajvir Kaur;Deepak N.Kapoor

作者机构：School of Pharmaceutical SciencesLovely Professional University School of Pharmaceutical SciencesShoolini University of Biotechnology and Management Sciences 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2018年第27卷第1期

页      面：31-39页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Imiquimod Condyloma acuminata Human papilloma virus Genital warts Nanoemulsions 

摘      要：In the present study,we aimed to formulate,optimize and characterize nanoemulsion-based gel of imiquimod for its topical administration and to improve the drug *** were prepared by the aqueous phase titration method and spontaneously formed by mixing specific fractions of oil phase:Smix:*** nanoemulsion formulations were optimized by response surface methodology(RSM) using mixture design,Scheffe *** formulated nanoemulsion was incorporated into 0.5% Carbopol 934(w/v) to enhance convenience in superficial application of the *** nanoemulsions were characterized in terms of droplet size,zeta potential,TEM,DSC and in vitro drug *** vesicle size was 113.6 nm with polydispersity index of *** zeta potential was 34 m *** spherical droplet shape was confirmed by TEM *** drug permeation from the diffusion membrane was 73.67% in 6 h for the optimized *** optimized nanoemulsion gel formulation of imiquimod was successfully developed with improved permeation using experimental design *** developed formulation could be further explored as a potential alternate to currently available topical formulations for the treatment of genital warts.