Construction of Multi-Substituted Benzenes via NHC-Catalyzed Reactions of Carboxylic Esters

作     者：Jichang Wu Chengli Mou Yonggui Robin Chi 

作者机构：Laboratory Breeding Base of Green Pesticide and Agricultural Bioengi- neering Key Laboratory of Green Pesticide and Agricultural Bioengi- neering Ministry of Education Guizhou University Huaxi District Gui- yang Guizhou 550025 China School of Pharmacy Guiyang College of Traditional Chinese Medicine Huaxi District Guiyang Guizhou 550025 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2018年第36卷第4期

页      面：333-337页

核心收录：

学科分类：081704[工学-应用化学] 081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 081701[工学-化学工程] 0703[理学-化学] 

基　　金：We acknowledge financial support by the National Natural Science Foundation of China (No. 21472028)  the National Key Technologies R&D Program (No. 2014BAD23B01)  the "Thousand Talent Plan"  the 10 Talent Plan (Shicengci) of Guizhou Province  Guizhou Province Returned Oversea Student Science and Technol- ogy Activity Program  and Guizhou University (China) 

主　　题：N-heterocyclic carbene carboxylic ester benzene synthesis organocatalysis TEMPO oxidation 

摘      要：A carbene-catalyzed ester activation reaction for the synthesis of multi-substituted benzenes is developed. Tetra-substituted benzene com- pounds are efficiently synthesized through this methodology. Compared with aldehyde substrates used in previous reports, the ester substrates used here are much more readily available and inexpensive. In addition, the TEMPO oxidant used here is more inexpensive than the quinones commonly used in related carbene-catalyzed reactions.