Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta

作     者：DU Jing DING Jie MU Zhen-Qiang GUAN Shu-Hong CHENG Chun-Ru LIU Xuan GUO De-An 

作者机构：School of Chemical Engineering Institute of Pharmaceutical Engineering Technology and Application Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education Sichuan University of Science & Engineering Shanghai Institute of Materia Medica Chinese Academy of Sciences Institute of Interdisciplinary Integrative Biomedical Research Shanghai University of Traditional Chinese Medicine 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2018年第16卷第2期

页      面：139-142页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81373964) Introduction Program of Scientific Researcher of Sichuan University of Science&Engineering(Nos.2016RCL07 and 2017RCL61) the Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education(No.LYJ1302) the Scientific Research Fund of the Sichuan Provincial Education Department(No.13ZB0133) the Science and Technology Program Project of Sichuan(No.2015JY0024) 

主　　题：Pinellia pedatisecta Alkaloids Structure identification Anti-tumor 

摘      要：The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids(compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl)methyl)-9 H-purin-6-amine(1), 4-(2-(2, 5-dioxopyrrolidin-1-yl)ethyl)phenyl acetate(2), and N-(9-((5-methoxypyridin-2-yl)methyl)-9 H-purin-6-yl)acetamide(3). These compounds were evaluated for their cytotoxicity against human cervical cancer He La cells. Compounds 1 and 3 significantly inhibited the proliferation of He La cells with IC_(50) values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L^(-1), respectively.