Exploring the mechanisms of Yinlai Decoction intervening the mice model of FM1 virus infected compound with high-fat and protein-diet

作     者：Shang Wang He Yu Jin feng Shi Yu Hao Tiegan Liu Chen Bai Jun Wu Zeji Qiu Xiaohong Gu 

作者机构：Beijing University of Chinese MedicineBeijing 100029China Hubei University of Chinese Medicine188 TanHualinWuchang DistrictWuhan 430061HubeiChina Zhengzhou No.2 Hospital of Chinese MedicineZhengzhou450000HenanChina 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2017年第4卷第4期

页      面：350-356页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：National Natural Science Foundation of China(81373769) Beijing Municipal Natural Science Foundation(7172131) Scientific research and postgraduate training project(1000062520040) Beijing University of Chinese Medicine Youth Teacher Research Project(2017-JYB-JS-012) 

主　　题：Influenza virus High-fat and protein-diet Yinlai Decoction Cytokines 

摘      要：Objective:To explore the mechanism of Yinlai Decoction (YD) intervening the mice model of FM1 influenza virus compound with high-fat and protein-diet by detecting the survival rate,lung injury,the expression of inflammatory ***:A high-fat and protein-diet mouse model was *** were randomly divided to groups of blank control,normal diet,high-fat and protein-diet (HPD),the Ribavirin,the Shuanghuanglian,the Xiaoer huashi Pill and the YD,all infected with FM1 virus via nose after four days high-fat and *** electrogastrography (EGG) was recorded,as well as the serum levels of the gastrin and plasma vasoactive intestinal peptide (VIP) were *** in the blank control group were shame-infected with 0.05 mL saline,while the mice in other groups were infected by 0.05 mL mouse lung-adapted FM1 *** were performed by stomach perfusion for next seven *** dose saline was given in the blank control,normal diet and HPD *** life protection and mean survival days were *** lung injuries were observed by H&rE *** expression of gastrin and VIP were detected by *** serum levels of IFN-γ,IL-4,IL-6,IL-10 and TNF-α were measured by ***:Compared with normal diet group,EGG dominant frequency,EGG swing,instability coefficient increased in HPD *** with HPD group,Ribavirin group and YD group showed significantly higher survival rate and IL-10 and IFN-γ levels significantly increased while the IL-6 and TNF-α levels significantly *** with blank control group,severe lung cirrhosis injuries were found in HPD group,and mild injuries were found in YD group and Ribavirin ***:The YD can regulate the level of cytokines,and improve the pathological damages of lung tissue,and then protect the mice with high-fat and protein-diet from being injured from the FM1 virus.