A race to uncover a panoramic view of primary liver cancer

作     者：Ruidong Xue Jing Li Fan Bai Xinwei Wang Junfang Ji Yinying Lu 

作者机构：Comprehensive Liver Cancer Center Beijing 302 Hospital of PLA Beijing 100039 China Translational Cancer Research Center Peking University First Hospital Beijing 100034 China Biodynamic Optical Imaging Center (BIOPIC) School of Life Sciences Peking University Beijing 100871 China Department of Gastroenterology Peking University People's Hospital Beijing 100044 China Clinical Center of Immune-Mediated Digestive Diseases Peking University People's Hospital Beijing 100044 China Laboratory of Human Carcinogenesis Center for Cancer Research National Cancer Institute Bethesda MD 20892 USA Life Sciences Institute Zhejiang University Hangzhou 310058 China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2017年第14卷第4期

页      面：335-340页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported,in part,by the Precision Medical Research Program from Ministry of Science and Technology of China(Grant No.YL 2017YFC0908400) National Science and Technology Major Project for Infectious Disease and Funding(Grant No.YL 17-163-12-ZT-005-095-01) Science and Technology Commission in Ministry of National Defense of China(Grant No.YL 17-163-12-ZT-005-095-01) Xinwei Wang was supported by the intramural research program of the Center for Cancer Research,National Cancer Institute of the United States Junfang Ji was supported by the Thousand Young Talents Plan of China,National Natural Science Foundation of China(Grant No.81672905) 

主　　题：A race to uncover a panoramic view of primary liver cancer 

摘      要：Introduction Primary liver cancer, the second most common cause of cancer related death worldwide, presents ethnic, etiological, sex, and geographical diversity2 （Figure 1A）. At the histological level, liver cancer includes two major types： hepatocellular carcinoma （HCC, about 80%） and cholangiocarcinoma （CCA, about 15%）. Many etiological factors contribute to HCC development, such as hepatitis B virus （HBV）, hepatitis C virus （HCV）, aflatoxin B1 （AFB1）, alcohol, and metabolic diseases3. By contrast, the major risk factors for CCA are liver flukes （Opisthorchis viverrini and Clonorchis sinensis） and primary sclerosing cholangitis4,