Effect of corticosteroids on atrial fibrillation after catheter ablation: a meta-analysis

作     者：Sanjay JAISWAL Xian-bao LIU Qu-cheng WEI Ying-hao SUN Li-han WANG Liu-guang SONG Dan-dan YANG Jian-an WANG 

作者机构：Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2018年第19卷第1期

页      面：57-64页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Atrial fibrillation Corticosteroids Catheter ablation Meta-analysis 

摘      要：Objective： The purpose of this meta-analysis was to explore the effect of corticosteroids on atrial fibrillation（AF） following catheter ablation. Methods： We searched Pub Med, Embase, and the Cochrane Central Register of Controlled Trials for published articles describing the effect of corticosteroids in preventing AF recurrence after catheter ablation. Data on study and patient were extracted. Risk ratios（RRs） and 95% confidence intervals（CIs） were calculated by use of a random-effect model, and P values of 〈0.05 were considered significant. Results： Two randomized controlled trials（RCTs） and three cohort studies involving 846 patients were included in this meta-analysis. Within one month of catheter ablation, corticosteroid use was associated with a declined risk of recurrence of AF in RCT（RR 0.57, 95% CI 0.39 to 0.85, P=0.005）, but without significant effect in cohort studies（RR 1.01, 95% CI 0.79 to 1.30, P=0.94）. After three months of catheter ablation, corticosteroids did not have a significant effect in the prevention of late recurrence of AF in either RCT（RR 0.78, 95% CI 0.38 to 1.59, P=0.49） or cohort studies（RR 0.96, 95% CI 0.70 to 1.31, P=0.78）. Conclusions： Our meta-analysis suggested that periprocedural administration of corticosteroids of catheter ablation was associated with reduction of early but not late recurrence of AF.