Fabrication of multiwalled carbon nanotube-surfactant modi fi ed sensor for the direct determination of toxic drug 4-aminoantipyrine

作     者：Jayant I.Gowda Arunkumar T.Buddanavar Sharanappa T.Nandibewoor 

作者机构：P.G. Department of Studies in Chemistry Karnatak University 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2015年第5卷第4期

页      面：231-238页

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：University Grants Committee  UGC 

主　　题：VoltammetryModified electrodeDiffusion controlled4 aminoantipyrinePharmacokinetic study 

摘      要：A multi-walled carbon nanotube （MWCNT）-cetyltrimethylammonium bromide （CRAB） surfactant com- posite modified glassy carbon electrode （GCE） was developed as a novel system for the determination of 4-aminoantipyrine（AAP）. The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CRAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0 x 10-9 to 4.0 x 10-8 M with a detection limit of 1.63 x 10 lo M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present elec- trochemical sensor based on the MWCNT-CFAB/GCE electrode was applied to the determination of AAP in real samples.