Mediator complex components are frequent targets for genetic alterations in various types of human cancer

作     者：Libin Deng Cheng Zhang Duling Miao Xiaoli Tang Shiwen Luo Hong-Bo Xin Huidong Shi 

作者机构：Institute of Translational MedicineNanchang UniversityNanchang 330031China Medical School of Nanchang UniversityNanchang 330031China Center for Experimental MedicineThe First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Biochemistry and Molecular BiologyMedical College of GeorgiaAugusta UniversityAugustaGA 30912USA Georgia Cancer CenterAugusta UniversityAugustaGA 30912USA 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2017年第44卷第12期

页      面：587-591页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：partially supported by the National Institutes of Health(R21CA185833 and R01GM113242 to H.S.) the National Natural Science Foundation of China(Nos.81660041 and 81260021 to L.D.) the Education Department of Jiangxi Province(GJJ150219to X.T.) 

主　　题：Mediator complex component frequent targets genetic alterations 

摘      要：The Mediator co-activator complex is a highly conserved,multisubunit protein complex required for gene transcription by RNA polymerase Ⅱ（RNAPⅡ）in all eukaryotes（Allen and Taatjes,2015）.This complex,which consists of at least 30 polypeptides,can be divided into four structurally distinct sub-modules including the head,middle,tail,and cyclin-dependent kinase 8（CDK8）modules （CKM） （Fig. 1A） （Yin and Wang, 2014; Allen and Taatjes, 2015）.