Generic synthesis and versatile applications of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures

作     者：Guiju Tao Zhengyuan Bai Yu Chen Heliang Yao Meiying Wu Ping Huang Luodan Yu Jiamin Zhang Chen Dai Long Zhang 

作者机构：Key Laboratory of Materials for High Power Laser Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800 China Sinopec Shanghai Research Institute of Petrochemical Technology Shanghai 201208 China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China Analysis and Testing Center for Inorganic Materials Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China Shanghai(Red Cross)Blood Center Shanghai Institute of Blood Transfusion Shanghai 200051 China Department of Ultrasound the East Hospital Affiliated to Tongji University Shanghai 200120 China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2017年第10卷第11期

页      面：3790-3810页

核心收录：

学科分类：07[理学] 

基　　金：We greatly acknowledge financial support from the National Key Research and Development Program of China (No. 2016YFA0203700)  Shanghai Natural Science Foundation (No. 16ZR1440300)  the National Natural Science Foundation of China (Nos. 61275208  51302293  and 51672303)  Shanghai Rising-Star Program (No. 14QA1404100)  Youth Innovation Promotion Associa- tion of the Chinese Academy of Sdences (No. 2013169) and Development Fund for Shanghai Talents (2015) 

主　　题：mesoporous organosilica Janus synthetic mechanism drug carrier blood compatibility 

摘      要：Precise control over the morphology,nanostructure,composition,and particle size of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles （MONs） still remains a major challenge,which severely restricts their broad *** this work an efficient bridged organic group-determined growth strategy has been proposed for the facile synthesis of highly dispersed and uniform MONs with multifarious Janus morphologies,nanostructures,organic-inorganic hybrid compositions,and particle sizes,which can be easily controlled simply by varying the bridged organic groups and the concentration of bis-silylated organosilica precursors used in the *** addition,the formation mechanism of Janus MONs determined by the bridged organic group has been *** on the specific structures,compositions,and asymmetric morphologies,all the synthesized Janus MONs with hollow structures （JHMONs） demonstrate excellent performances in nanomedicine as desirable drug carriers with high drug-loading efficiencies/capacities,pH-responsive drug releasing,and enhanced therapeutic efficiencies,as attractive contrastenhanced contrast agents for ultrasound imaging,and as excellent bilirubin adsorbents with noticeably high adsorption capacities and high blood *** developed versatile synthetic strategy and the obtained JHMONs are extremely important in the development and applications of MONs,particularly in the areas of nanoscience and nanotechnology.