Transcription Factors:Potential Cell Death Markers in Parkinson's Disease

作     者：Ronglin Wang Shaosong Yang Tiejian Nie Gang Zhu Dayun Feng Qian Yang 

作者机构：Department of Neurosurgery Tangdu Hospital The Fourth Military Medical University Xi'an 710038 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2017年第33卷第5期

页      面：552-560页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China (2016YFC1306603) the National Natural Science Foundation of China (31671060) 

主　　题：Parkinson＇s disease · Transcription factor  Biomarker · Cell death · Dopaminergic neuron 

摘      要：Parkinson＇s disease （PD） is a neurodegenerative disease with a long preclinical phase. The continuous loss of dopaminergic （DA） neurons is one of the pathogenic hallmarks of PD. Diagnosis largely depends on clinical observation, but motor dysfunctions do not emerge until 70%-80% of the nigrostriatal nerve terminals have been destroyed. Therefore, a biomarker that indicates the degeneration of DA neurons is urgently needed. Transcrip- tion factors are sequence-specific DNA-binding proteins that regulate RNA synthesis from a DNA template. The precise control of gene expression plays a critical role in the development, maintenance, and survival of cells, including DA neurons. Deficiency of certain transcription factors has been associated with DA neuron loss and PD. In this review, we focus on some transcription factors and discuss their structure, function, mechanisms of neuropro- tection, and their potential for use as biomarkers indicating the degeneration of DA neurons.