Gene editing in T cell therapy

作     者：Yongping Zhang Wei Mu Haoyi Wang 

作者机构：State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Department of Hematology Aerospace Center Hospital Aerospace Clinical Medical College Peking University University of Chinese Academy of Sciences 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2017年第44卷第9期

页      面：415-422页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071007[理学-遗传学] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (No. 31471215) the National High-tech R&D Program (863 Program) (2015AA020307) supported by the "Young Thousand Talent Project" 

主　　题：Gene editing CRISPR Cas9 T cells 

摘      要：The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise. Gene editing holds tremendous potential for further improvements of T cell therapy. Here we review the applications of gene editing in various T cell therapies, focusing on antiviral strategies and cancer immunotherapies, and discuss the challenges and future prospects.