Amyotrophic Lateral Sclerosis： Precise Diagnosis and Individualized Treatment

作     者：Qing-Qing Tao Zhi-Ying Wu Tao Qing-Qing;Wu Zhi-Ying

作者机构：Department of Neurology and Research Center of Neurology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2017年第130卷第19期

页      面：2269-2272页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071003[理学-生理学] 

主　　题：Amyotrophic Lateral Sclerosis Individualized Treatment Precise Diagnosis 

摘      要：INTRODUCTION Amyotrophic lateral sclerosis （ALS） is a progressive neurodegenerative disease characterized by selective death of upper motor neurons （UMNs） and lower motor neurons （LMNs）, typically may die from respiratory failure within 2-5 years of symptorn onset）H About 10% orALS patients are familial whereas the remaining patients are sporadic. ALS is highly heterogeneous in genetic and clinical phenotype, with lack of definitive diagnostic tools, making it extremely difficult to make early diagnosis.