The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

作     者：Bo Zhao Wen-wei Gao Ya-jing Liu Meng Jiang Lian Liu Quan Yuan Jia-bao Hou Zhong-yuan Xia 

作者机构：Department of AnesthesiologyRenmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Critical Care MedicineRenmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第10期

页      面：1632-1639页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.81471844 the Natural Science Foundation of Hubei Province of China,No.2016CFB167 the Basic Scientific Research Foundation of Central Universities,No.2042017kf0147 

主　　题：nerve regeneration myocardial ischemia/reperfusion injury brain injury glycogen synthase kinase 3 beta ischemic post conditioning diabetes mellitus neural regeneration 

摘      要：Myocardial ischemia/reperfusion injury can lead to severe brain *** synthase kinase 3 beta is known to be involved in myocardial ischemia/reperfusion injury and diabetes ***,the precise role of glycogen synthase kinase 3 beta in myocardial ischemia/reperfusion injury-induced brain injury is *** this study,we observed the effects of glycogen synthase kinase 3 beta on brain injury induced by myocardial ischemia/reperfusion injury in diabetic *** models of diabetes mellitus were generated via intraperitoneal injection of *** of myocardial ischemia/reperfusion injury were generated by occluding the anterior descending branch of the left coronary ***-conditioning comprised three cycles of ischemia/*** staining and western blot assays demonstrated that after 48 hours of reperfusion,the structure of the brain was seriously damaged in the experimental rats compared with normal *** of Bax,interleukin-6,interleukin-8,terminal deoxynucleotidyl transferase d UTP nick end labeling,and cleaved caspase-3 in the brain was significantly increased,while expression of Bcl-2,interleukin-10,and phospho-glycogen synthase kinase 3 beta was *** mellitus can aggravate inflammatory reactions and *** post-conditioning with glycogen synthase kinase 3 beta inhibitor lithium chloride can effectively reverse these *** results showed that myocardial ischemic post-conditioning attenuated myocardial ischemia/reperfusion injury-induced brain injury by activating glycogen synthase kinase 3 *** to these results,glycogen synthase kinase 3 beta appears to be an important factor in brain injury induced by myocardial ischemia/reperfusion injury.