Copper-Catalysed Decarboxylative Trifluoromethylation of β-Ketoacids
Copper-Catalysed Decarboxylative Trifluoromethylation of β-Ketoacids作者机构:School of Chemistry and Chemical Engineering Hefei University of Technology Hefei Anhui 230009 China School of Medical Science Anhui Medical University Hefei Anhui 230009 China
出 版 物:《Chinese Journal of Chemistry》 (中国化学(英文版))
年 卷 期:2017年第35卷第11期
页 面:1665-1668页
核心收录:
基 金:We gratefully acknowledge financial support from the National Natural Science Foundation of China (21472033) and the Fundamental Research Funds for the Central Universities. We thank Wen-Man Zhang and Bei Huang in this group for reproducing the results of compounds 3c 3e and 3m
主 题:β-ketoacids decarboxylative trifluoromethylation α-trifluoromethyl ketones
摘 要:An efficient method for Cu-catalyzed decarboxylative trifluoromethylation offl-ketoacids to achieve a-trifluoro- methyl ketones was developed. A wide variety of synthetically useful α-trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method also exhibits good functional-group compatibility.