Copper-Catalysed Decarboxylative Trifluoromethylation of β-Ketoacids

作     者：Xiaolan Xu Huanhuan Chen Jianbo He Huajian Xu 

作者机构：School of Chemistry and Chemical Engineering Hefei University of Technology Hefei Anhui 230009 China School of Medical Science Anhui Medical University Hefei Anhui 230009 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2017年第35卷第11期

页      面：1665-1668页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：We gratefully acknowledge financial support from the National Natural Science Foundation of China (21472033) and the Fundamental Research Funds for the Central Universities. We thank Wen-Man Zhang and Bei Huang in this group for reproducing the results of compounds 3c  3e  and 3m 

主　　题：β-ketoacids decarboxylative trifluoromethylation α-trifluoromethyl ketones 

摘      要：An efficient method for Cu-catalyzed decarboxylative trifluoromethylation offl-ketoacids to achieve a-trifluoro- methyl ketones was developed. A wide variety of synthetically useful α-trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method also exhibits good functional-group compatibility.