Pharmacokinetics and pharmacodynamics of cisatracurium in children undergoing cleft lip or cleft palate repair surgery

作     者：Wei-jia HAO LI Jing-yi Yi MA Jie XIONG Ping-xiang XU Yu-hang LI Xiao-tong ZHANG Xiao-rong LI 

作者机构：Capital Medical UniversityDepartment of PharmacologySchool of Basic Medical Sciences Capital Medical UniversityBeijing Friendship Hospital Capital Medical UniversityBeijing Stomatological Hospital 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2017年第31卷第10期

页      面：1021-1022页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Top Young Innovative Talents of Beijing(CIT&TCD201404174) Basic Clinical Cooperation Project of Capital Medical University(14JL79) 

主　　题：cisatracurium children PK/PD 

摘      要：OBJECTIVE The aim of the study was to characterize the pharmacokinetics(PK) and pharmacodynamics(PD) profile of cisatracurium in 0-2 years and 2-5 years old children patients with cheilopalatognathus,to find if there are some connections between the different muscle relaxation action and different PK *** 14 children patients were divided into two groups,≤2 years and 2-5 years group,venous samples were taken before injection of a 0.15 mg·kg-1 dose of cisatracurium and then at 2,5,10,30,60,90,and 120 *** plasma concentrations were determined by ultra-performance liquid chromatography/electrospray ionization/triple quadrupole tandem mass spectrometer system(UPLC/MS/MS).The degree of neuromuscular block was measured by train of four(TOF) *** indirect PK-PD link model with a sigmoid E max model was established using Win Nonlin *** model were applied to PK and PD data analysis,*** The TOF monitor parameters showed that cisatracurium works very quickly,the onset time were(2.64±0.93) min and(2.59 ± 0.90) min for ≤2 years and 2-5 years group *** children ≤2 years have longer muscle blocking duration time(62.5 ± 6.01 min vs 53.86 ± 12.18 min) and slower recovery index(32.14±7.10 min and 27.43±10.63 min) than those children in group of 2-5 *** children ≤2 years have postoperative complication than that in 2-5 *** parameters showed that there were no statistical differences in blood concentration and pharmacokinetic *** the concentration of cisatracurium in muscle site calculated by using PK/PD model were higher and longer for ≤2 year children than that of 2-5 year *** means that cisatracurium could stay at high concentration for a longer time in younger children muscle *** As a result young children tend to have postoperative complications related to slower muscle recovery action and increased concentration in skeletal *** more careful observat