Prognostic role of ABO blood type in patients with extranodal natural killer/T cell lymphoma,nasal type:a *** study

作     者：Ya.JunLi Ping.YongYi Ji.WeiLi Xian.LingLiu Tian Tang Pei.YingZhang Wen.QiJiang 

作者机构：Department of Lymphoma and HematologyHunan Cancer Hospital283 Tongzipo RoadYuelu DistrictChangsha 410013HunanP.R.China The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013HunanP.R.China Cancer Center of the Second Xiangya HospitalCentral South UniversityChangsha 410013HunanP.R.China Radioactive Interventional DepartmentHunan Cancer HospitalChangsha 410013HunanP.R.China Integration Medicine DepartmentHunan Chest HospitalChangshaHunan 410013P.R.China Department of Medical OncologySun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dong Feng RD EastGuangdong 510060GuangdongP.R.China 

出 版 物：《Chinese Journal of Cancer》 (Chinese Journal of Cancer)

年 卷 期：2017年第36卷第9期

页      面：427-437页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the grants from the Hunan Provincial Science and Technology Department(No.2016JJ3083) the grants from the Heath and Family Planning Commission of Hunan Province(No.c2015-52) 

主　　题：ABO blood type Extranodal natural killer/T-cell lymphoma Prognosis The International Prognostic Index The Korean Prognostic Index 

摘      要：Background:The prognostic significance of ABO blood type for lymphoma is largely *** evaluated the prognostic role of ABO blood type in patients with extranodal natural killer(NK)/T-cell lymphoma(ENKTL).Methods:We retrospectively analyzed clinical data of 697 patients with newly diagnosed ENKTL from three cancer *** prognostic value of ABO blood type was evaluated using Kaplan-Meier curves and Cox proportional hazard *** prognostic values of the International Prognostic Index(IPI) and the Korean Prognostic Index(KPI)were also ***:Compared with patients with blood type O,those with blood type non-O tended to display elevated baseline serum C-reactive protein levels(P=0.038),lower rate of complete remission(P=0.005),shorter progression-free survival(PFS,P60 years(P0.001),mass ≥5 cm(P=0.001),stage Ⅲ/Ⅳ(P0.001),elevated serum lactate dehydrogenase(LDH) levels(P=0.001),and blood type non-O were independent adverse predictors of OS(P=0.001).ABO blood type was found to be superior to both the IPI in discriminating patients with different outcomes in the IPI low-risk group and the KPI in distinguishing between the intermediate-to-low-and high-to-intermediate-risk ***:ABO blood type was an independent predictor of clinical outcome for patients with ENKTL.