Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential

作     者：XU Zhiling LIAN Xiaowei LI Mengjie ZHANG Xiaodong WANG Yi TAO Zhu ZHANG Qianjun 

作者机构：Research and Development Center of Fine Chemicals Guizhou University Guiyang 550025 P R. China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province College of Chemistry and Chemical Engineering Guizhou University Guiyang 550025 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2017年第33卷第5期

页      面：736-741页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 083201[工学-食品科学] 

基　　金：Supported by the National Natural Science Foundation of China(No.21272045) 

主　　题：Chrysin Cucurbituril hMusion complex Solubility Stability Antioxidant activity 

摘      要：The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The results show that CHR forms a 1：1 inclusion complex with Q[8], with a binding constant of CHR with Q[8] by UV absorp- tion being 5.4 × 106. Phase solubility experiments show a 5.13-fold increase in the solubility of CHR through interac- tion with Q[8] {c（Q[8]）=10-4 real/L}. A study of the evolution of UV absorption spectra with time shows that Q[8] significantly increases the stability of CHR. The antioxidant activity of CHR-Q[8] has been tested by the ABTS me- thod. The CHR-Q[8] inclusion complex shows a better scavenging effect towards the ABTS radical than CHR, with respective IC50 values of 1.05 ×10-6 and 3.07× 10-6 mol/L. In vitro release studies have shown that CHR-Q[8] has a sustained release effcct.