Genome-wide analysis reveals selection for Chinese Rongchang pigs

作     者：Lei CHEN Shilin TIAN Long JIN Zongyi GUO Dan ZHU Lan JING Tiandong CHE Qianzi TANG Siqing CHEN Liang ZHANG Tinghuan ZHANG Zuohua LIU Jinyong WANG Mingzhou LI 

作者机构：Key Laboratory of Pig Industry SciencesMinistry of AgricultureChongqing Academy of Animal Sciences Institute of Animal Genetics and Breeding/College of Animal Science and TechnologySichuan Agricultural University 

出 版 物：《Frontiers of Agricultural Science and Engineering》 (农业科学与工程前沿（英文版）)

年 卷 期：2017年第4卷第3期

页      面：319-326页

学科分类：0905[农学-畜牧学] 09[农学] 

基　　金：supported by the National High Technology Research and Development Program of China (2013AA102502) Chongqing Agricultural Development Foundation (12404,14440 and 15428) the National Natural Science Foundation of China (31372284,31401073,31472081,31522055,31601919 and 31601930) the Program for Innovative Research Team of Sichuan Province (2015TD0012) the National Program for Support of Top-notch Young Professionals, the Young Scholars of the Yangtze River 

主　　题：domestication genome pig re-sequencing selection 

摘      要：Livestock have undergone domestication and consequently strong selective pressure on genes or genomic regions that control desirable traits. To identify selection signatures in the genome of Chinese Rongchang pigs, we generated a total of about 170 Gb of DNA sequence data with about 6.4-fold coverage for each of six female individuals. By combining these data with the publically available genome data of 10 Asian wild boars,we identified 449 protein-coding genes with selection signatures in Rongchang pigs, which are mainly involved in growth and hormone binding, nervous system development, and drug metabolism. The accelerated evolution of these genes may contribute to the dramatic phenotypic differences between Rongchang pigs and Chinese wild boars. This study illustrated how domestication and subsequent artificial selection have shaped patterns of genetic variation in Rongchang pigs and provides valuable genetic resources that can enhance the use of pigs in agricultural production and biomedical studies.