药物与天然产物:从动植物到人类疾病的治疗（英文）

作     者：Benedict T GREEN Stephen LEE 

作者机构：Poisonous Plant Research LaboratoryUnited States Department of Agriculture 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2017年第31卷第10期

页      面：946-946页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：plant toxicity livestock 

摘      要：Plants toxic to livestock species have a significantly negative impact on agriculture but can be an important source of bioactive molecules for use in *** initial research on plant toxicity is focused on the response to the poisoning and the specific livestock species impacted by the toxic *** research emphasizes the identification of the plant and natural product(s)responsible for the toxicity to livestock,the prevention of further poisonings,and the development of treatments for the affected *** the bioactive molecules impacting the livestock species have been identified,research on these compounds is then focused on determining the mechanism of action,the development of models for further study,and the identification of potential drug candidates for the treatment of *** examples of the agricultural-based research that are relevant to Human and Veterinary Medicine include:cyclopamine from Veratrum californicum(western false hellebore),piperidine alkaloids fromLupinus species(lupines),and cicutoxin from Cicuta species(water hemlock).