Effect of carboxymethyl cellulose on dissolution kinetics of carboxymethyl cellulose-sodium carbonate two-component tablet

作     者：Changdong Li Carlos Amador Yulong Ding 

作者机构：Institute of Particle Science and EngineeringUniversity of Leeds Leeds UK School of Engineering University of Warwick. Coventry. CV4 7AL UK Procter & Gamble Newcastle-Upon-Tyne Innovation Centre Newcastle UK School of Chemical Engineering University of Birmingham Birmingham UK 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2017年第25卷第10期

页      面：1545-1550页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：the Institute of Particle and Science Engineering University of Leeds and Procter & Gamble Newcastle Innovation Centre(UK) for partially funding the project 

主　　题：Carboxymethyl cellulose Sodium carbonate Electrical conductivity Temperature Surface reaction model Dissolution rate constant 

摘      要：Sodium carbonate and carboxymethyl cellulose powders are compressed into two-component tablets with three mass ratios,97%:3%,95%:5% and 93%:7%.The dissolution tests for two-component tablets and reference pure sodium carbonate tablets are carried out at various *** dissolution process of each tablet is measured by electrical conductivity tracking method and the concentration of dissolved sodium carbonate is quanti fied with calibrated conductivity-concentration converting equation of sodium *** quanti fied dissolution data is fitted with both surface reaction model and diffusion layer model and the results clearly show that surface reaction model is suggested as the appropriate dissolution model for all measured ***,it is determined that carboxymethyl cellulose is a stable element to remain the dissolution mechanism of tablet *** dissolution rate constant quanti fied with surface reaction model presents that carboxymethyl cellulose-sodium carbonate two-component tablets obtain signi ficant higher dissolution rate constant than pure sodium carbonate tablet and higher proportion of carboxymethyl cellulose leads to apparent higher dissolution rate *** results prove for the usage of carboxymethyl cellulose in most practical applications at a relative low-level,the effect of carboxymethyl cellulose is effective and positive for two-component tablet to enhance the dissolution process and improve dissolution rate constant and this effect is speculated coming from its dynamic physical transforming process in water including dilation and conglutination.