Qingre Lishi Tuihuang therapy for acute icteric hepatitis B: A systematic review

作     者：Zisong Wang Xueqian Wang Jiajie Zhu Fafeng Cheng Haiqiang Yao Zheng Yang Zengliang Zhang Qingguo wang 

作者机构：Beijing University of Chinese MedicineBeijing 100029China Department of GastroenterologyWangjing HospitalChina Academy of Traditional Chinese MedicineBeijing 100102China Traditional Chinese Medicine CollegeInner Mongolia Medical UniversityHohhot 010110China 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2017年第4卷第2期

页      面：95-105页

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The study was partially supported by Chinese National Natural Science Foundation Project(81373886).We really appreciate Mei Han Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine for her suggestions in data synthesis 

主　　题：Qingre Lishi Tuihuang therapy Acute icteric hepatitis B Systematic review Traditional Chinese medicine 

摘      要：Objective:To assess the efficacy of Qingre Lishi Tuihuang therapy (QLTT) for acute icteric hepatitis B ***:Eight electronic databases were searched from inception to December 2016 with no language restrictions for reports of randomized controlled trials evaluating the effect of QLTT treating acute icteric hepatitis *** researchers independently extracted detailed data and assessed methodological *** 5.3.0 software was used to analyze the ***:A total of 13 randomized controlled trials involving 2238 participants were included in this *** methodological quality was generally *** results indicated that supplemented Yinchenhao decoction combined with non-specific treatments was more effective in improving the cure rate (risk ratio =1.80;95% CI 1.21-2.68) and reducing the serum levels of total bilirubin (mean difference =-29.74;95% CI-31.91 to-27.57) and aspartate *** self-made prescriptions conforming to QLTT plus non-specific treatments had beneficial effect for acute icteric hepatitis B in curing this disease (risk ratio =1.48;95% CI 1.27-1.73),as well as for negative seroconversion of HBeAg (risk ratio =1.39;95% CI 1.11-1.74).Supplemented Yinchenhao decoction plus non-specific treatments was more effective than other self-made prescriptions conforming to QLTT in reducing serum total bilirubin ***:Qingre Lishi Tuihuang therapy appears to improve effect based on non-specific treatments for the treatment of acute icteric hepatitis ***,it is premature to draw confirmative conclusions,owing to the poor methodological quality and high clinical heterogeneity of the included *** well-designed clinical randomized controlled trials with large sample sizes should be undertaken.