RNA Regulations and Functions Decoded by Transcriptome-wide RNA Structure Probing

作     者：meiling piao lei sun qiangfeng cliff zhang 

作者机构：moe key laboratory of bioinformaticsbeijing advanced innovation center for structural biologycenter for synthetic and systems biologytsinghua-peking joint center for life sciencesschool of life sciencestsinghua universityBeijing 100084China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2017年第15卷第5期

页      面：267-278页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：supported by the National Natural Science Foundation of China(Grant No.31671355) the National Thousand Young Talents Program of China to QCZ 

主　　题：RNA structure probing RNA structurome RNA secondary structure Structure-function relation-ship RNA regulation 

摘      要：RNA folds into intricate structures that are crucial for its functions and regulations. To date, a multitude of approaches for probing structures of the whole transcriptome, i.e., RNA struc- turomes, have been developed. Applications of these approaches to different cell lines and tissues have generated a rich resource for the study of RNA structure-function relationships at a systems biology level. In this review, we first introduce the designs of these methods and their applications to study different RNA structuromes. We emphasize their technological differences especially their unique advantages and caveats. We then summarize the structural insights in RNA functions and regulations obtained from the studies of RNA structuromes. And finally, we propose potential directions for future improvements and studies.