A Brief Review of Short Tandem Repeat Mutation

作     者：Hao Fan Jia-You Chu 

作者机构：Institute of Medical Biology Chinese Academy of Medical Sciences Kunming 650118 China Biochemistry Department Kunming Medical College Kunming 650031 China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2007年第5卷第1期

页      面：7-14页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

主　　题：short tandem repeats mutation 

摘      要：Short tandem repeats （STRs） are short tandemly repeated DNA sequences that involve a repetitive unit of 1-6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.