Feasibility of orthotopic fetal liver transplantation:an experimental study

作     者：Xian-Ping Zhou,Xue-Ping Zhou,Wei-Hua Pan,Wei Gong,Cheng-Ren Shi and Zhi-Wei Quan Department of General Surgery and Department of Pediatric Surgery , Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China 

作者机构：Department of General Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 China Shanghai China Department of Pediatric Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 China Shanghai China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2012年第11卷第2期

页      面：143-147页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by a grant from the Science and Technology Commission of Shanghai Municipality(07-JC14045) 

主　　题：surgical anatomy operative surgery survival time experimental surgery 

摘      要：BACKGROUND:The use of livers from nonviable fetuses is particularly attractive for its potential to solve the current limitations of organ availability for the pediatric ***,it is essential to study the feasibility of orthotopic fetal liver ***:We measured the hepatic and extra-hepatic anatomical structures of fetal and neonatal lambs and established an orthotopic liver transplantation model of the fetal ***:Mean weight of the liver of fetal lambs at 142 to 145 days gestation was 34.75 g and the mean diameter of the portal vein was 3.03 mm,the supra-hepatic vena cava was 5.88 mm,and the infra-hepatic vena cava was 4.00 mm,which matched the corresponding sizes in neonatal lambs aged up to 2 *** standard surgical procedures we completed the vascular inosculation of fetal ***,all the newborn lamb recipients survived less than 24 ***:Orthotopic transplantation of the fetal liver is anatomically and technically ***,perioperative issues need to be resolved prior to clinical application.