Construction of Recombinant Modified Vaccinia Ankara(MVA) Expressing Hepatitis B Virus Surface Antigen

作     者：CHEN Yu YANG Xiao-song YU Xiang-hui JIANG Chun-lai WU Yong-ge JIN Ying-hua CHEN Yue CHEN Yan LI Wei KONG Wei 

作者机构：Vaccine Research Center College of Life Science Jilin University Changchun 130012 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2006年第22卷第2期

页      面：213-216页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0703[理学-化学] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Recombinant MVA Therapeutic vaccine T lymphocyte response 

摘      要：The T lymphocyte response has been shown to be the determinant in the clearance of many viral infections. Hence, therapeutic vaccine candidates against HBV are designed to enhance this response of the immune system. Vaccinia virus vector-based vaccines have been proposed as excellent candidates to elicit long-term and strong T lymphocyte mediated immune responses. In this study, the recombinant MVA expressing HBV surface antigen has been constructed, which can elicit a potent T cell mediated response. The ELISA results for the surface protein in the medium of the recombinant MVA, strongly indicate that the recombinant virus has been successfully obtained.