Determination of trace amounts of morphine in human plasma by anodic adsorptive stripping differential pulse voltammetry

作     者：Ali Niazi Ateesa Yazdanipour 

作者机构：Department of ChemistryFaculty of SciencesAzad University of ArakArakIran 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第4期

页      面：465-468页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Morphine Adsorptive differential pulse voltammetry Human plasma 

摘      要：New adsorptive anodic differential pulse stripping voltammetry method for the direct determination of morphine at trace levels in human plasma of addicts is *** procedure involves an adsorptive accumulation of morphine on a HMDE,followed by oxidation of adsorbed morphine by voltammetry scan using differential pulse *** optimum conditions for the analysis of morphine are pH 10.5,Eacc of -100 mV（***/AgCl）,and tacc of 120 *** peak current is proportional to the concentration of morphine,and a Linear calibration graph is obtained at 0.01-3.10μg mL^-1.A relative standard deviation of 1.06%（n=5）was obtained,and the limit of detection was 3 ng mL^-*** capabiLity of the method for the analysis of real samples was evaluated by the determination of morphine in spiked human plasma and addicts human plasma with satisfactory results.