Recent advances in mitochondria-and lysosomes-targeted small-molecule two-photon fluorescent probes

作     者：Peng Ning Wenjuan Wang Man Chen Yan Feng Xiangming Meng 

作者机构：School of Chemistry and Chemical Engineering & Center for Atomic Engineering of Advanced Materials & Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials Anhui University Hefei 230601 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第10期

页      面：1943-1951页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (Nos. 21778001, 21372005) the Anhui Provincial Natural Science Foundation (No. 1608085MB39) the Natural Science Foundation of Education Department of Anhui Province (No. KJ2015A047) the 211 Project of Anhui University 

主　　题：Two-photon absorption Fluorescent probe Localization Mitochondria Lysosomes 

摘      要：Mitochondria and lysosomes are essential cellular organelles in most eukaryotic cells by playing the physiological roles to support the normal functions of cells, as well as the life of the whole body. To date,small-molecule fluorescent probes have been considered as one of the vital tools for monitoring and visualizing multiple biological analytes. This review summarized the recent advances in small-molecule two-photon fluorescent probes for metal ions, reactive oxygen species（ROS） and reactive sulfur species（RSS）, and changes inside micro-environment（e.g., p H, viscosity and polarity） in mitochondria and lysosomes, or served as mitotracker and lysotracker with the assistance of two-photon microscopy.