Tetraphenylethene End-capped Polyethylenimine Fluorescent Nanoparticles for Cell Imaging

作     者：张锡奇 Xiao-yong Zhang Bin Yang 危岩 

作者机构：Department of Chemistry and the Center for Frontier Polymer ResearchTsinghua University 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2014年第32卷第11期

页      面：1479-1488页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 0817[工学-化学工程与技术] 08[工学] 070205[理学-凝聚态物理] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.21134004,21201108 and 51363016) the National 973 Project(No.2011CB935700) China Postdoctoral Science Foundation(Nos.2012M520243 and 2013T60100) 

主　　题：Aggregation-induced emission Polyethylenimine Schiff base condensation Fluorescent organic nanoparticles Cell imaging. 

摘      要：Water soluble tetraphenylethene-based（TPE） aggregation-induced emission fluorescent organic nanoparticles（FONs） were facilely prepared via Schiff base condensation with polyethylenimine（PEI） and subsequent reduction. The obtained TPE-PEI FONs were characterized by a series of techniques including 1H-NMR, 13C-NMR, gel permeation chromatography, UV absorption spectra, fluorescence spectra, Fourier transform infrared spectroscopy, size distribution and zeta potential measurement, and transmission electron microscopy. Biocompatibility evaluation and cell imaging of TPE-PEI FONs were further explored. We demonstrated that such FONs showed intense fluorescence, spherical morphology and excellent biocompatibility, making them very suitable for cell imaging application.