A facile protocol for N-Cbz protection of amines in PEG-600
A facile protocol for N-Cbz protection of amines in PEG-600作者机构:Beijing Key Laboratory of Active Substance Discovery and Druggability EvaluationInstitute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2012年第23卷第7期
页 面:789-792页
核心收录:
学科分类:081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学]
基 金:the National Science and Technology Project of China(No.2009ZX09102-054)for financial support
主 题:Benzyl chloroformate (Cbz-C1) N-Cbz protection Amines PEG-600
摘 要:An efficient and eco-friendly protocol for the chemoselective N-benzyloxycarbonylation of amines was *** reaction of amines with benzyl chloroformate(Cbz-Cl) in the presence of PEG-600 at room temperature afforded the corresponding N-Cbz derivatives in excellent *** method is applicable to the N-Cbz protection of aliphatic(acyclic and cyclic) and aromatic amines.