A facile protocol for N-Cbz protection of amines in PEG-600

作     者：Chun Lin Zhang Dong Feng Zhang Hong Yi Zhao Zi Yun Lin Hai Hong Huang 

作者机构：Beijing Key Laboratory of Active Substance Discovery and Druggability EvaluationInstitute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2012年第23卷第7期

页      面：789-792页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：the National Science and Technology Project of China(No.2009ZX09102-054)for financial support 

主　　题：Benzyl chloroformate (Cbz-C1) N-Cbz protection Amines PEG-600 

摘      要：An efficient and eco-friendly protocol for the chemoselective N-benzyloxycarbonylation of amines was *** reaction of amines with benzyl chloroformate（Cbz-Cl） in the presence of PEG-600 at room temperature afforded the corresponding N-Cbz derivatives in excellent *** method is applicable to the N-Cbz protection of aliphatic（acyclic and cyclic） and aromatic amines.