Near-infrared chemical imaging for quantitative analysis of chlorpheniramine maleate and distribution homogeneity assessment in pharmaceutical formulations
作者机构：Beijing University of Chinese MedicineP.R.China 100102 Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine(TCM)of Ministry of EducationP.R.China 100102 Key Laboratory of TCM-information Engineering of State Administration of TCM BeijingP.R.China 100102 Beijing Key Laboratory for Basic and Development Research on Chinese Medicine BeijingP.R.China 100102
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2016年第9卷第6期
页 面：12-20页
核心收录：
学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学]
基 金：supported from Beijing Municipal Government for the university a±liated with the Party Central Committee(Prof.Shi) National Natural Science Foundation of China(81303218) Doctoral Fund of Ministry of Education of China(20130013120006) Special Fund of Beijing University of Chinese Medicine(Manfei Xu)
主 题：Near infrared chemical imaging partial least squares regression assessment of distributional homogeneity chlorpheniramine maleate
摘 要：Near infrared chemical imaging(NIR-CI)combines conventional near infrared(NIR)spectros-copy with chemical imaging,thus provides spectral and spatial information simult *** could be utilized to visualize the spatial distribution of the ingredients in a *** data acquired using NIR CI instrument are hyperspectral data cube(hypercube)containing thousands of *** methodologies are necessary to transform spectral information into chemical *** least squares(PLS)method was performed to extract chemical information of chlorpheniramine maleate in pharmaceutical formulations.A series of samples which consisted of different CPM concentrations(w/w)were compressed and hypercube data were *** spectra extracted from the hypercube were used to establish the PLS model of *** results of the model were R^(2)_(val)0.981,RMSEC 0.384%,RMSECV 0.483%,RMSEP 0.631%,indicating that this model was reliable.
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