Anti-inflammatory,analgesic and antipyretic activity of methanolic Tecomaria capensis leaves extract

作     者：Neeraj Kuniar Saini Manmohan Singhal 

作者机构：Jaipur National UniversityJaipurStale-Rajasthan 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2012年第2卷第11期

页      面：870-874页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by management ofJaipur National University Jaipur India 

主　　题：Pain Inflammation Fever Nociception Tecomaria capensis Analgesic Antipyretic Methanol 

摘      要：Objective:To evaluate the analgesic,anti-inflammatory and antipyretic activity of methanolic Tecomaria capensis(***) leaves extract using different models in ***: Methanolic *** leaves extract(100,300,1000 and 2000 mg/kg body weight) was given to rats orally to observe acute toxicity,and observed for 14 *** activity was evaluated using tail immersion and formalin induced paw licking models in ***-inflammatory activity was evaluated using carrageenan induced paw edema model in *** activity was evaluated using brewer s yeast induced pyrexia model in *** *** leaves extract were given at dose of 100,200 and 500 mg/kg ***:Results demonstrated that the no mortality was reported even after 14 *** indicated that the methanol extract was safe up to a single dose of 2000 mg/kg body weight Methanolic 71 capensis leaves extract(100,200 and 500 mg/kg p.o.) significantly increased the latency period in the tail immersion test,reduced the licking time in both the neurogenic and inflammatory phases in the formalin *** *** leaves extract(100,200 and 500 mg/kg p.o.) significantly prevented increase in volume of paw edema. Methanolic *** leaves extract at the doses of(100,200 and 500 mg/kg p.o.) significantly decreased the rectal temperature of the ***:This study exhibites that methanolic T. capensis leaves extract possesses analgesic,anti-inflammatory and antipyretic activity which may be mediated by the central and peripheral mechanisms.