p16 gene methylation in colorectal cancers associated with Duke's staging

作     者：Jing Yi~1 Zhi-Wei Wang~1 Hui Cang~1 Yu-Ying Chen~1 Ren Zhao~2 Bao-Ming Yu~2 Xue-Ming Tang~1 1 Department of Cell Biology,2 Department of Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China 

作者机构：Department of Cell Biology Shanghai Second Medical University 280 Chongqing South Road Shanghai 200025 China. yijing@*** 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2001年第7卷第5期

页      面：722-725页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the grants from Mjnistry of Public Health of China,No.98-1-303 The Educational Committee of Shanghai,No.2000B02 

主　　题：DNA Methylation Colorectal Neoplasms CpG Islands Female Genes, p16 Humans Male Middle Aged Neoplasm Staging Polymerase Chain Reaction Research Support, Non-U.S. Gov't 

摘      要：AIM: To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers. METHODS: Methylation-specific PCR (MSP) was used to detect p16 methylation of 62 sporadic colorectal cancer specimens. RESULTS: p16 methylation was detected in 42% of the *** staging was associated with p16 methylation status.p16 methylation occurred more frequently in Dukes C and D patients (75.9%) than in Dukes A and B patients (12.1%). CONCLUSION: p16 methylation plays a role in the carcinogenesis of a subset of colorectal cancer, and it might be linked to poor prognosis.