Combination of OCT and Raman spectroscopy for improved characterization of atherosclerotic plaque depositions

作     者：Kokila Egodage Christian Matthaus Sebastian Dochow Iwan W.Schie Carmen Hardtner Ingo Hilgendorf Jürgen Popp 

作者机构：Leibniz Institute of Photonic TechnologyAlbert Einstein Straβe 9Jena 07745Germany Institute of Physical Chemistry and Abbe Center of PhotonicsFriedrich-Schiller-UniversityJena 07743Germany University Heart Center FreiburgDepartment of Cardiology and Angiology IFaculty of MedicineUniversity of FreiburgGermany 

出 版 物：《Chinese Optics Letters》 (中国光学快报（英文版）)

年 卷 期：2017年第15卷第9期

页      面：31-35页

核心收录：

学科分类：0808[工学-电气工程] 070207[理学-光学] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0803[工学-光学工程] 0702[理学-物理学] 10[医学] 

基　　金：supported by the Carl Zeiss Foundation 

主　　题：Combination of OCT and Raman spectroscopy for improved characterization of atherosclerotic plaque depositions 

摘      要：The biochemical composition of atherosclerotic plaques is closely related to plaque stability and, therefore, to the associated risk of plaque evolution and rupture. Combinations of current imaging modalities, such as optical coherence tomography（OCT） with spectroscopic methods, therefore offer the possibility of concurrently obtaining morphological as well as chemical information. Raman spectroscopy is one of the most promising techniques that can be combined with intravascular imaging modalities. A microscopy setup merging both techniques has been applied to characterize plaque depositions of a human aorta affected by the disease. Calcified depositions were clearly identified and subsequently confirmed by histopathology.