Measuring the physical and economic impact of filarial lymphoedema in Chikwawa district,Malawi:a case-control study

作     者：Michelle C.Stanton Masato Yamauchi Square Z.Mkwanda Paul Ndhlovu Dorothy Emmie Matipula Charles Mackenzie Louise A.Kelly-Hope 

作者机构：Department of ParasitologyLiverpool School of Tropical MedicineLiverpoolUK Ministry of HealthLilongweMalawi Chikwawa District Health OfficeChikwawaMalawi Chiradzulu District Health OfficeChiradzuluMalawi Department of Pathobiology and Diagnostic InvestigationMichigan State UniversityEast LansingUSA 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2017年第6卷第1期

页      面：234-242页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Liverpool School of Tropical Medicine with grant support from the UK Department for International Development(DFID) The funder did not have any role in any aspect of this study 

主　　题：Lymphatic filariasis Lymphoedema Morbidity Malawi GPS Mobility Quality of life 

摘      要：Background:Lymphatic filariasis(LF)is one of the primary causes of lymphoedema in sub-Saharan Africa,and has a significant impact on the quality of life(QoL)of those *** this paper we assess the relative impact of lymphoedema on mobility and income in Chikwawa district,***:A random sample of 31 people with lymphoedema and 31 matched controls completed a QoL questionnaire from which both an overall and a mobility-specific score were *** mobility tests were undertaken,namely the 10 m walking test[10MWT]and timed up and go[TUG]test,and a subset of 10 casescontrol pairs wore GPS data loggers for 3 weeks to measure their mobility in a more natural *** economic data was collected from all 31 case-control pairs,and each participant undertaking the GPS activity recorded daily earnings and health expenditure throughout the observation ***:Cases had a significantly poorer overall QoL(cases=32.2,controls=6.0,P0.01)and mobility-specific(cases=43.1,controls=7.4,P0.01)scores in comparison to *** were also significantly slower(P0.01)at completing the timed mobility tests,*** 10MWT speed of 0.83 m/s in comparison to 1.10 m/s for *** inconsistent relationship was observed between mobility-specific QoL scores and the timed test results for cases(10MWT correlation=−0.06,95%CI=(−0.41,0.30)),indicating that their perceived disability differed from their measured disability,whereas the results were consistent for controls(10MWT correlation=−0.61,95%CI=(−0.79,−0.34)).GPS summaries indicated that cases generally walk shorter distances at slower speeds than control,covering a smaller geographical area(median area by kernel smoothing:cases=1.25 km2,controls=2.10 km^(2),P=0.16).Cases reported earning less than half that earned by controls per week(cases=$0.70,controls=$1.86,P=0.064),with a smaller proportion of their earnings(16%vs 22%,P=0.461)being spent on ***:Those affected by lymphoede