Levels of insecticide resistance to deltamethrin,malathion,and temephos,and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands(French West Indies)
作者机构：Laboratory of Medical EntomologyUnit Environment and HealthPasteur Institute of Guadeloupe97183 Les AbymesGuadeloupe Vector control ServiceRegional Health AgencyDothemareLes AbymesGuadeloupe Alpine Ecology Laboratory(LECA)CNRSUMR 55532233 rue de la piscine BP5338041 GrenobleCedex 9France University of Grenoble AlpesGrenobleFrance Environmental and Systems Biology(BEeSy)University of Grenoble AlpesGrenobleFrance Vector Environment and Society UnitSpecial Programme for Research and Training in Tropical Diseases(TDR)World Health Organization20Avenue AppiaCH-1211 Geneva 27Switzerland
出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)
年 卷 期：2017年第6卷第1期
页 面：339-353页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：This study was financially supported by the Fonds Europeen de Developpement Economique et Regional project FED-1-1.432932 by the ARS through the collaboration convention no°2014-140116 DG was supported by La Region Guadeloupe,Le Fond Social Europeen,and the University of Antilles
主 题：Aedes aegypti Mosquitoes Insecticide resistance Deltamethrin Malathion Temephos Guadeloupe Saint Martin
摘 要：Background:In the Guadeloupe and Saint Martin islands,Aedes aegypti mosquitoes are the only recognized vectors of dengue,chikungunya,and Zika *** around 40 years,malathion was used as a mosquito adulticide and temephos as a *** the European Union banned the use of these two insecticide molecules in the first decade of the 21st century,deltamethrin and Bacillus thuringiensis *** are the remaining adulticide and larvicide,respectively,used in *** order to improve the management of vector control activities in Guadeloupe and Saint Martin,we investigated *** resistance to and mechanisms associated with deltamethrin,malathion,and ***:*** mosquitoes were collected from six different localities of Guadeloupe and Saint *** were used for malathion and temephos bioassays,and adult mosquitoes for deltamethrin bioassays,following World Health Organization *** resistance(Kdr)genotyping for V1016I and F1534C mutations,and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora ***:Resistance ratios(RR50)calculated for *** larvae showed high resistance levels to temephos(from 8.9 to 33.1-fold)and low resistance levels to malathion(from 1.7 to 4.4-fold).Adult females displayed moderate resistance levels to deltamethrin regarding the time necessary to affect 50%of individuals,varying from 8.0 to *** investigations on adult mosquitoes showed high resistant allele frequencies for V1016I and F1534C(from 85 to 96%and from 90 to 98%,respectively),as well as an overexpression of the glutathione S-transferase gene,GSTe2,the carboxylesterase CCEae3a,and the cytochrome genes 014614,CYP6BB2,CYP6M11,and ***:*** populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates(temephos and malathion),and pyrethroids(deltamethrin
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