Effects of All-trans Retinoic Acid (ATRA) against Bacterial Infection in Chickens
Effects of All-trans Retinoic Acid(ATRA) against Bacterial Infection in Chickens作者机构：College of Animal Science and Veterinary Medicine Tianjin Agricultural University Tianjin 300384 China
出 版 物：《Agricultural Biotechnology》 (农业生物技术（英文版）)
年 卷 期：2017年第6卷第4期
页 面：25-27,47页
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
基 金：Supported by Project of Educational Reform,Innovation,Guidance and Development for College Teachers in Tianjin Agricultural University(20171003) Student's Platform for Innovation and Entrepreneurship Training Program(201610061008,201710061045)
主 题：All-trans retinoic acid (ATRA) Escherichia coli Pasteurella Chickens Anti-infection Weight Immune organ index
摘 要：In order to investigate the effects of all-trans retinoic acid （ATRA） against bacterial infection in chickens, 35 3-day-old AA broiler chickens were fed adaptively for two days and randomly divided into five groups, including Escherichia coli experimental group （ group 1 ）, Escherichia coli control group （group 2）, blank control group （ group 3 ）, PasteureUa experimental group （ group 4）, and PasteureUa control group （ group 5 ）. At 5 days of age, the chickens in group 1 and group 4 were drenched with 5 ***/kg ATRA for seven consecutive days according to their weight; the chickens in group 2, group 3 and group 5 were drenched with an equal volume of dimethyl sulfoxlde （DMSO）. The clinical symptoms and weight changes in each group were observed and recorded. Seven days later, the chickens were euthanized and dissected to determine the immune organ indexes. The results showed that there were significant differences in body weight between ATRA-administrated chickens and non-administrated chickens after bacterial infection （P 〈 0.05 ） ; moreover, the immune organ indexes of ATRA-administrated chickens exhibited significant differences compared with control group （P 〈 0.05 ）, indicating that ATRA could promote the development of immune organs of poultry, thereby enhancing the body immunity against bacterial infection.
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