咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >Changes with aging in gastric ... 收藏

Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population

Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population

作     者:Jin-Hua Shan Xiao-Juan Bai Lu-Lu Han Yuan Yuan Xue-Feng Sun 

作者机构:Department of Gerontology and Geriatricsthe First Affiliated Hospital of China Medical University Department of Gerontology and GeriatricsShengjing Hospital of China Medical University Department of Tumor Researchthe First Affiliated Hospital of China Medical University Department of KidneyGeneral Hospital of Chinese People’s Liberation Army 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2017年第23卷第32期

页      面:5945-5953页

核心收录:

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基  金:Supported by the National Basic Research Program of China(973 Program) No.2007CB507405,No.2013CB530803 and No.2013CB530804 

主  题:Helicobacter pylori antibody Pepsinogen Gastrin Gastric ageing 

摘      要:AIM To observe changes in gastric biomarker levels with age and effects of Helicobacter pylori(H. pylori) infection in a healthy population, and explore factors associated with gastric *** Three hundred and ninety-five subjects were selected and underwent physical examinations, biochemical tests, and measurement of serum pepsinogen(PG)Ⅰ and Ⅱ, gastrin-17(G-17) and H. pylori antibody levels. Analyses were made by Student s t-test, ANOVA, Pearson s correlation and multiple linear *** PGII levels were higher in the ≥ 65-years-old age group(P 0.05) and PGI/PGII were lower in the ≥ 75-years-old age group(P = 0.035) compared to the 35-44-years-old age group. Levels of low-density lipoprotein cholesterol(LDL-C) were higher(P = 0.009) in H. pylori-infected subjects that were male. LDL-C levels were higher in 55-74-years-old age group(P 0.05) for H. pylori-infected subjects and 45-64-yearsold age group(P 0.05) for non-infected subjects compared to 35-44-years-old age group. Hp-Ig G level positively correlated with PGⅠ, PGⅡ and G-17(P 0.001, P 0.001, P = 0.006), and negatively correlated with PGI/PGII(P 0.001). Creatinine positively correlated with PGⅠ, PGⅡ and G-17(P 0.001, P 0.001, P 0.001). Fasting blood glucose(FBG) positively correlated with PGⅠ/PGⅡ and G-17(P 0.001, P = 0.037). Age positively correlated with PGII and G-17(P = 0.005, P = 0.026).CONCLUSION PGII levels increased while PGI/PGII declined with age in a healthy population. H. pylori infection had an effect on raising LDL-C levels to increase the risk of atherosclerosis in males, especially those of elderly age. Age, H. pylori infection, levels of renal function and FBG were associated with levels of pepsinogens and gastrin.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分