Studies on photodynamic mechanism of a novel chlorine derivative(TDPC)and its antitumor effect forphotodynamic therapy in vitro and in vivo
作者机构：Department of Pharmaceutical Science&Technology College of Chemistry and BiologyDonghua University Shanghai 201620P.R.China Changhai HospitalSecond Military Medical University Shanghai 200433P.R.China
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2015年第8卷第1期
页 面：60-67页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by Chinese National Natural Science Foundation (21372042,81301878,81101298) Foundation of Shanghai government (13431900700,13430722300,13ZR1441000,13ZR1440900) Foundation of Donghua University (No.11D10501,12D10515) Foundation of Yiwu Science and Technology Bureau (2011-G1-15,2012-G3-02)
主 题：Photosensitizer photodynamic therapy tumor chlorin TDPC
摘 要：Photodynamic therapy(PDT)represents a promising method for treatment of cancerous *** chemical and physical properties of used photosensitizer(PS)play key roles in the treat ment *** this study,a novel PS,5,10,15,20-tetrais((5-dipropylamino)pentyl)-chlorin(TDPC)which displayed a characteristic long wavelength absorption peak at 650 nm were *** also shows a singlet oxygen generation rate of 4.257 min^(-1).Generally,TDPC is localized in mitochondria and nucleus of *** light irradiation with 650 nm laser,it can kill many types of cell,in addition,TDPC-PDT can destroy ECA-109 tunor in nude mice and a necrotic scab was formed *** expression levels of many genes which regulated cell growth and apoptosis were determined by RT-PCR following *** results showed that it either increased or decreased,among which,the expression level of TNFSF13,a member of tumor necrosis factor superfamily,increased *** general,TDPC is an elective antitumor PS in vitro and in vito and is worthy of further study as a new drug ***13 will be an important molecular target for the discovery of new PSs.
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