Clinical characteristics of fatigued Parkinson’s patients and the response to dopaminergic treatment
到 dopaminergic 治疗的使疲劳的 Parkinsons 病人和反应的临床的特征作者机构：Neurology DepartmentOutpatient of Parkinson’s DiseaseFirst Affiliated Hospital of China Medical University155#Nanjing bei streetHeping DistrictShenyang 110001P R China
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2016年第5卷第1期
页 面：75-81页
核心收录：
基 金：This work was funded by the China National Nature Science Fund(no.30973153) Liaoning Doctoral Starting Fund(20071042) the Foundation of the Liaoning Educational Committee(L202013136,L2010560)
主 题：Parkinson’s disease Fatigue Sleep disorder Depression Dopaminergic drugs
摘 要：Background:Fatigue,which is commonly observed in Parkinson’s disease(PD),can greatly reduce quality of life and is difficult to *** here aimed to investigate the prevalence and characteristics of fatigue among PD patients and to explore an effective strategy to treat PD ***:This was an observational cross-sectional study conducted in northeastern *** examined fatigue in 222 PD patients from northeastern China using the Parkinson Fatigue Scale-16(PFS-16).The disease severity,depression,sleep and cognitive functioning were assessed with the Hoehn&Yahr staging(H-Y stage),Unified Parkinson’s Disease Rating Scale(UPDRS),Hamilton Depression Scale(HAMD),Parkinson’s Disease Sleep Scale(PDSS)and Montreal Cognitive Assessment(MoCA)by ***:The frequency of fatigue in PD patients was 59.46%.Fatigued patients had longer disease durations and greater disease severity than nonfatigued ***,fatigued PD patients scored significantly higher for all motor symptoms,except for tremor,and had more serious depressive symptoms and sleep disturbances than nonfatigued PD patients *** sleep disturbance severity was an independent factor for ***,43.04% of fatigued patients taking dopaminergic drugs had fatigue *** severity was identified as an independent factor for dopaminergic drug non-responsive ***:PD patients with severe sleep disturbances tend to suffer from *** improved fatigue only in PD patients with mild depression or no depression,implying that dopaminergic medication is required,but not sufficient,for fatigue suppression in PD patients with moderate or severe ***,restoring serotonergic neurotransmission as a combination therapy may offer a better strategy for the treatment of fatigue in these patients.
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